Amniocentesis and Chorionic Villus Sampling (Green-top Guideline No. 8)

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Corresponding Author

the Royal College of Obstetricians, Gynaecologists

Publish date

10/25/2021
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Key recommendations

  • Women should be informed that the additional risk of miscarriage following amniocentesis or CVS performed by an appropriately trained operator is likely to be below 0.5%. [Grade B]
  • Amniocentesis should not be performed prior to 15+0 weeks’ gestation. [Grade A]
  • CVS should not be performed prior to 10+0 weeks’ gestation. [Grade D]
  • Where possible, to reduce the risk of technical challenges, CVS should be performed from 11+0 weeks’ gestation onwards. [Good Practice Point]
  • Women with multiple pregnancies should be informed that the additional risk of miscarriage for twin pregnancy following CVS or amniocentesis performed by an appropriately trained operator is around 1%. [Grade B]
  • Screening results for blood borne viruses, viral load and antigen test results should be reviewed when an invasive test is considered and individualised risk of viral transmission should be discussed. [Grade C]

View and download the guideline

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